It has an effect if one chamber (or face) is buggered, Image a S@W 357 mag with a stuffed chamber one will always not work properly, shoot a bad group 

 it's why we count all the parts that make up the 6 shots, just like in our donkey engines. 
All the chambers count to make a whole rig that will work well, faces, pistons does not matter, we dont just look at one alone, we look at all parts of the system 
We are talking the same things I think